ComicsMarvel ComicsSpider-ManOne of Marvel’s oldest supervillain teams just reunited with its classic line-upWhen you purchase through links on our site, we may earn an affiliate commission.Here’s how it works.
ComicsMarvel ComicsSpider-ManOne of Marvel’s oldest supervillain teams just reunited with its classic line-upWhen you purchase through links on our site, we may earn an affiliate commission.Here’s how it works.
When you purchase through links on our site, we may earn an affiliate commission.Here’s how it works.
(Image credit: Marvel Comics)

Following the end of Gang War, Amazing Spider-Man #45 sets up the next big threat that Spider-Man will face. But it’s more than just one big villain - it’s six.
And if you’ve been a fan of Spider-Man long enough, you know exactly how dangerous that number can be for the Friendly Neighborhood Wall-Crawler.
Spoilers ahead for Amazing Spider-Man #45
Spider-Man delivers a cure for the poison to Aunt Anna, whose murderous rage subsides. She elects to stay in confinement as a result of her actions, in which she hurt people due to being poisoned. Spidey reluctantly leaves her, respecting her decision.
(Image credit: Marvel Comics)

Back at OsCorp, Peter tries to resign, to focus more on being Spider-Man. But Norman Osborn rejects his resignation, telling him to stay on at full salary while still operating as Spider-Man, further cementing the growing bond between Peter and Norman.
But when Peter mentions that their mutual friend is Spider-Man, Sandman flips out, with a “sonic inhibitor” that he wears pulling him back together before he can cause any harm. Apologetically, Sandman tells Peter to give Spider-Man a warning - that Flint Marko, his evil side, is trying to come out - and that “they want him out too.”
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(Image credit: Marvel Comics)

Though Sandman doesn’t tell Peter who “they” are, Peter knows, and we’re shown explicitly on the next page exactly who it is - the rest of the originalSinister Six: Doctor Octopus, Mysterio, Kraven, Vulture, and Electro.
(Image credit: Marvel Comics)

But now, with the original team back together (with Sandman trying to avoid being sucked in again), Spider-Man may be facing one of his most deadly threats in some time. And with the return of the Green Goblin already foreshadowed for Amazing Spider-Man #50, it’s looking like Peter Parker is going to be dealing with most of his top enemies for a while, with Chasm and Hallow’s Eve also set to return before #50.
Amazing Spider-Man #45 is out now fromMarvel Comics. Amazing Spider-Man #46 goes on sale March 27.
Most of the members of the Sinister Six are among thebest Spider-Man villainsof all time.
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1
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2Mufasa: The Lion King review – “It’s no Hakuna Matata but this Disney origin story is a class above the 2019 movie”
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5Creature Commandos review: “James Gunn’s heartwarming, R-rated tale about super-monsters proves that the DCU is in good hands”
5
Creature Commandos review: “James Gunn’s heartwarming, R-rated tale about super-monsters proves that the DCU is in good hands”